FMRF-NH2-like mammalian octapeptide: possible role in opiate dependence and abstinence |
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| Authors: | D H Malin J R Lake M V Hammond D E Fowler R B Rogillio S L Brown J L Sims B M Leecraft H Y Yang |
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| Affiliation: | University of Houston-Clear Lake, TX 77058. |
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| Abstract: | Yang et al. have isolated from bovine brain an octapeptide, FLFQPQRF-NH2 (F-8-F-NH2), with certain antiopiate properties. Malin et al. previously found that ICV injection of this peptide could precipitate an opiate abstinence syndrome in dependent rats. RIA revealed significantly higher levels of F-8-F-NH2 immunoreactivity in CSF withdrawn from the cisterna magna of morphine-dependent rats as opposed to CSF withdrawn from sham-implanted controls. ICV infusion of IgG from antiserum against F-8-F-NH2 significantly reduced the number of abstinence signs subsequently precipitated by naloxone in morphine-dependent rats. |
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