Determination of proliferative parameters from growth curves |
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Authors: | R. Cowan V. B. Morris |
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Affiliation: | CSIRO Division of Mathematics and Statistics, Box 218 Lindfield, NSW 2070;*School of Biological Sciences, Zoology AO8, University of Sydney, NSW 2006, Australia |
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Abstract: | Abstract. Data on total cell numbers and proportions of non-proliferative cells during the development of a tissue can be obtained by experiment. This paper shows, via a simple mathematical model, that data collected over a period of time determine the time profile of two proliferative parameters. These are the rate per proliferative cell per day at which cells divide and the average number of proliferative daughters which result from the division of a proliferative cell. One dataset alone does not provide sufficient information to determine either time profile. The findings are applicable where there is no significant cell death during the growth period. The mathematical model is fitted to data from chick neural retina. |
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