Immune-Enhancing Activity Screening on Extracts from Two Crickets, Gryllus bimaculatus and Teleogryllus emma |
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| Authors: | SEO Dong-Hwan&dagger ,Seock-Yeon HWANG&dagger ,Jikhyon HAN,Sang-Kyun KOH,Iksoo KIM,Kang Sun RYU,Chi-Young YUN |
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| Affiliation: | Dept. of Clinical Laboratory Medicine, Chungbuk National University Hospital, Cheongju 360-240, Korea;Dept. of Microbiology, Daejeon University, Daejeon 300-716, Korea;Dept. of Sericulture and Entomology, National Institute of Agricultural Science and Technology, Suwon 441-857, Korea;Dept. of Biology, Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 300-716, Korea |
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| Abstract: | This study was performed to explore novel and valuable uses of insect resources, important subjects of the natural compound used in bio‐industries. The whole bodies of two crickets, Gryllus bimaculatus and Teleogryllus emma, selected from medicinal insect species, were carefully ground and treated with 80% EtOH. The insect extracts were solubilized and separated by hexane, butanol, and D.W according to their polarities. Three types of extracts, a D.W fraction (G1) and a boiling extract (G2) of an introduced cricket, G. bimaculatus, and a D.W fraction (T1) of a Korean local cricket, T. emma, were prepared to assay immune stimulating activity of cricket originated compounds. The all of three treated cricket extracts showed to increase IL‐4, IFN‐, and TNF‐α. Among those extract, extract G2, boiled extract from G. bimaculatus, was the best immune–enhancing fraction. The results of this study could be fundamental information for further works to use insects as natural resources having plenty of potentials and varieties. |
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| Keywords: | Immune-enhancing activity Medicinal insect Cricket Gryllus bimaculatus Teleogryllus emma |
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