PI3K 与乙型肝炎病毒宫内感染的相关研究

慢性乙型肝炎病毒(Hepatitis B virus,HBV)感染是全世界关注的公共卫生问题。我国是乙肝高流行区,每年约有150万乙肝病毒携带者分娩,近半数胎儿通过母婴垂直传播感染乙肝。由于婴幼儿期感染乙肝后形成的免疫耐受,往往成为慢性甚至终身携带者,逐渐发展为肝硬化、肝癌。近年来的研究发现,PI3-Akt信号通路与妊娠生及或病理过程关系密切,在感染HBV的胎盘组织中发现PI3K-Akt信号通路中相关蛋白表达异常增高,且HBx Ag干扰该通路调节凋亡功能。推断HBx Ag通过调节PI3K-Akt信号通路活性影响胎盘功能,是HBV宫内感染的一种重要分子机制。为今后阻断HBV宫内感染提供新的研究方向。

PI3K Intrauterine Infection with Hepatitis B Virus

Chronic hepatitis B virus (Hepatitis B virus, HBV) infection is a public health problem of worldwide concern. Of highhepatitis B prevalence area, each year about 1.5 million hepatitis B virus carriers childbirth, about 80 million children may be infectedthrough vertical transmission. Infant immune tolerance phase of infection, the infection often become chronic and even lifelong carriers,and the development of cirrhosis, liver cancer. Recent studies have found that the PI3-Akt signaling pathway pregnancy Health andpathological processes of close relationship, the study found abnormally high levels of PI3K-Akt signaling pathway protein found in theplacental tissue infected with HBV, and interfere with the pathway HBxAg withered The perish function. To infer HBxAg affectplacental function by regulating the activity of PI3K-Akt signaling pathway, an important molecular mechanism of HBV intrauterineinfection. Provide a new direction for future blocking HBV intrauterine infection.