1.José Carreras Center and Internal Medicine I; University of Saarland Medical Center; Homburg, Germany;2.Institute of Virology; University of Saarland Medical Center; Homburg, Germany;3.Helmholtz Center; Institute for Molecular Immunology; Munich, Germany;4.Institute of Human Genetics; Center of Human and Molecular Biology; Medical Faculty; University of Saarland; Homburg, Germany