IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection |
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| Authors: | Ara Lee Seung Pyo Park Chan Hee Park Byung Hyun Kang Seong Hoe Park Sang-Jun Ha Kyeong Cheon Jung |
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| Affiliation: | 1. Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea.; 2. Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.; 3. Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea.; 4. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.; North Carolina State University, UNITED STATES, |
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| Abstract: | Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL–4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-γ and TNF-α with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection. |
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