唾液的增加加速了含羧甲基壳聚糖口香糖的抗菌效果

目的:本论文采用了含羧甲基壳聚糖的口香糖,咀嚼这种口香糖的机械效果加速了其对口腔细菌的抑制作用,还比较口腔嗽洗液和咀嚼口香糖的抗菌效果,证明了通过咀嚼这种口香糖加速了唾液的分泌.方法:从青岛大学口腔科的老师和学生中选取了12名健康的受试者.在测试前取受试者的唾液测试细菌含量.在测试口香糖的试验中,受试者咀嚼5分钟口香糖然后休息5分钟.在测试口腔嗽洗液时,受试者用10ml嗽洗液漱口30秒后,休息9分30秒.同一天中这些测试步骤在50分钟内连续不断的进行了5次.5次测试后分别在0、30和60min收集被试者的唾液测试细菌含量.在测试唾液分泌的试验中,受试者每天咀嚼三次口香糖持续两天.结果:与使用口腔嗽洗液相比,咀嚼含羧甲基壳聚糖口香糖的受试者,在三个取样时间内口腔细菌的含量基本都明显减少,但是在60分钟的取样时间结果有点差异.咀嚼含羧甲基壳聚糖的口香糖明显提高了唾液的分泌量.结论:咀嚼含羧甲基壳聚糖的口香糖具有明显的抗菌效果.目前的研究结果强有力的证明了:使用像壳聚糖以及其衍生物这样的天然物质,对我们的口腔健康以及生活质量都有很大的帮助.

Carboxymethyl Chitosan-containing gum chewing accelerates antibacterial effect with an increase in salivary secretion

Objectives:This study was designed to verify the mechanical efficacy of chewing carboxymethyl chitosan-containing gum to suppress the growth of oral bacteria compared to a mouth rinse,and to demonstrate the increased salivary secretion due to chewing carboxymethyl chitosan-containing gum.Methods:Twelve healthy subjects were recruited from the staff and students of Qingdao University School of Dentistry.For the slab of gum study,the subjects chewed carboxymethyl chitosan-containing gum for 5 min and then rested for 5 min.For the testing of the carboxymethyl chitosan mouth rinse solution,the subjects gargled 10 mlof solution for 30s followed by a rest of 9min and 30s.These protocols were continuously repeated five times within 50 min on the same day.For the salivary secretion experiment,the gum chewing was repeated three times per day for 2days.Results:The amount of oral bacteria in the subjects who chewed carboxymethyl chitosan-containing gum significantly decreased during all three sampling times except at 60 min for total bacteria in comparison with those in the rinse group.Carboxymethyl chitosan-containing gum chewing also significantly mcreased the secretion of saliva.Conclusions:Carboxymethyl chitosan-containing gum chewing has a greater antibacterial effect and it also increases salivary secretion.The present findings strongly indicate that the application of natural materials such as carboxymethyl chitosan is useful for both oral health and the quality of life.