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| 葡萄球菌生物膜形成机制与ica之间的关系 | |
| 引用本文： | 唐俊妮,周 锐,王红宁,史贤明,陈焕春. 葡萄球菌生物膜形成机制与ica之间的关系[J]. 微生物学通报, 2008, 35(8): 1287-1291 |
| 作者姓名： | 唐俊妮 周 锐 王红宁 史贤明 陈焕春 |
| 作者单位： | 1. 四川大学生命科学学院动物疾病防控生物工程研究中心,成都,610065;华中农业大学农业微生物国家重点实验室,武汉,430070 2. 华中农业大学农业微生物国家重点实验室,武汉,430070 3. 四川大学生命科学学院动物疾病防控生物工程研究中心,成都,610065 4. 上海交通大学食品科学与工程系陆伯勋食品安全研究中心,上海,200240 |
| 基金项目： | 国家科技支撑计划重大项目，中国博士后科学基金 |
| 摘 要： | ica位点编码的胞外多糖(PIA/PNAG)对理解葡萄球菌生物膜相关感染病理学方面具有重要的意义.关于ica位点与PIA/PNAG之间如何调节的研究还不全面,另外一种独立于ica的生物膜形成机制存在于表皮葡萄球菌和金黄色葡萄球菌中;细胞表面相关蛋白也能调节生物膜的形成,这些发现为探究它们在生物膜形成机制的潜在作用提供了重要基础. |
| 关 键 词： | 葡萄球菌 生物膜 形成机制 |
The Relationship Between Staphylococcal Biofilm Formation Mechanism and ica locus |
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| TANG Jun-Ni,ZHOU Rui,WANG Hong-Ning,SHI Xian-Ming and CHEN Huan-Chun. The Relationship Between Staphylococcal Biofilm Formation Mechanism and ica locus[J]. Microbiology China, 2008, 35(8): 1287-1291 | |
| Authors: | TANG Jun-Ni ZHOU Rui WANG Hong-Ning SHI Xian-Ming CHEN Huan-Chun |
| Affiliation: | (1. Bioengineering Research Center for Animal Disease Prevention and Control, School of Life Science, Sichuan University, Chengdu 610065)(2. State Key Laboratory of Agricultural Microbiology and College of Veterinary Medicine, Huazhong Agricultural Univer;State Key Laboratory of Agricultural Microbiology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070;Bioengineering Research Center for Animal Disease Prevention and Control, School of Life Science, Sichuan University, Chengdu 610065;Department of Food Science and Technology and Bor Luh Food Safety Center, Shanghai Jiao Tong University, Shanghai 200240;State Key Laboratory of Agricultural Microbiology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070 |
| Abstract: | The role of the ica locus-encoded polysaccharide intercellular adhesin (PIA/PNAG) has contributed a lot to the pathogenesis of device-related infections of staphylococcal biofilm. Understanding of how the ica locus and PIA/PNAG biosynthesis are regulated is not enough. Another biofilm formation mechanism of ica-independent in both Staphylococcus aureus and Staphylococcus epidermidis exists. The cell surface associated proteins are capable of mediating biofilm formation. Future research about their potential role in biofilm development will be very important. |
| Keywords: | PIA/PNAG ica |
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