A new chromosome anomaly in acute lymphoblastic leukemia (ALL) |
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| Authors: | H. Van den Berghe G. David A. Broeckaert-Van Orshoven A. Louwagie R. Verwilghen M. Casteels-Van Daele E. Eggermont R. Eeckels |
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| Affiliation: | (1) The Division of Human Genetics, University of Leuven, Minderbroedersstraat 12, B-3000 Leuven, Belgium;(2) The Division of Hematology and Pediatrics, University of Leuven, B-3000 Leuven, Belgium;(3) Department of Human Biology and Medical Research, University of Leuven, B-3000 Leuven, Belgium;(4) Department of Developmental Biology, University of Leuven, B-3000 Leuven, Belgium |
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| Abstract: | Summary A new chromosome anomaly in acute lymphoblastic leukemia (ALL) is reported. Three, possibly four, patients showed an identical karyotype anomaly, characterized by a (4;11)(q13;q22) reciprocal translocation. This anomaly has not so far been found in lymphoproliferative disorders other than ALL. Two of the patients had congenital leukemia, but the anomaly described appears to be more characteristic of ALL than of congenital leukemia, and may help the clinician in establishing the diagnosis of ALL. |
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