与人体β—珠蛋白基因5‘旁侧正调控区（PCR）相结合的调控因子（简报） Transacting factors binding to the positive control region (PCR) in the 5' flanking sequence of human beta-globin gene]期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

与人体β—珠蛋白基因5‘旁侧正调控区（PCR）相结合的调控因子（简报）

引用本文：	陈士友谢恒月. 与人体β—珠蛋白基因5‘旁侧正调控区（PCR）相结合的调控因子（简报）[J]. 实验生物学报, 1997, 30(2): 221-223

作者姓名：	陈士友谢恒月

摘要：
关键词：	基因表达 β－珠蛋白基因正调控区调控因子
Transacting factors binding to the positive control region (PCR) in the 5' flanking sequence of human beta-globin gene]

S Y Chen,H Y Xie,C Jiang,R L Qian. Transacting factors binding to the positive control region (PCR) in the 5' flanking sequence of human beta-globin gene][J]. Acta Biologiae Experimentalis Sinica, 1997, 30(2): 221-223

Authors:	S Y Chen H Y Xie C Jiang R L Qian

Affiliation:	Shanghai Institute of Cell Biology, Academia Sinica.

Abstract:	Using gel mobility shift assay, three protein factors (Pa, Pb, Pc) binding to the positive control region (PCR) in the 5' flanking sequence of human beta-globin gene were detected in the nuclear extracts from mouse fetal liver at d 18 or d 19 of gestation. Competitive experiment showed that Pb and Pc could bind to GATA-1 motif, therefore could be the members of GATA family. While Pa was a new and developmental stage specific trans-acting factor, we suggested that the factor Pa was related to the activation of beta-globin gene.

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