| 大鼠侧脑室注射高渗盐水引起血压上升过程中心房钠尿肽和血管升压素的变化 |
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| 引用本文： | 罗勇,张琪,赵秀文,刘冬青,孙双丹,丁金凤. 大鼠侧脑室注射高渗盐水引起血压上升过程中心房钠尿肽和血管升压素的变化[J]. 生理学报, 1991, 43(1): 94-97 |
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| 作者姓名： | 罗勇 张琪 赵秀文 刘冬青 孙双丹 丁金凤 |
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| 作者单位： | 中国医学科学院心血管病研究所、阜外医院 北京100037(罗勇，张琪，赵秀文，刘冬青，孙双丹)，中国医学科学院心血管病研究所、阜外医院 北京100037(丁金凤) |
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| 摘 要： | 为研究中枢渗透压刺激升压的机制,在大鼠侧脑室内给予高滲人工脑脊液,记录颈动脉压和心率变化,给药10min 后,用放射免疫法测定血浆、下丘脑和垂体中的心房钠尿肽和升压素。结果表明:中枢给予高渗人工脑脊液后,血浆中升压素水平明显增加,心房钠尿肽没有明显改变,下丘脑和垂体中的心房钠尿肽含量增加,而升压素含量下降。
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| 关 键 词： | 心房钠尿肽 血管升压素 侧脑室注射 中枢渗透压感受器 大鼠 |
CHANGES IN ATRIAL NATRIURETIC PEPTIDE AND VASOPRESSIN DURING THE PRESSOR RESPONSE TO CENTRAL OSMOTIC STIMULATION |
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| LUO YONG,ZHANG QI. CHANGES IN ATRIAL NATRIURETIC PEPTIDE AND VASOPRESSIN DURING THE PRESSOR RESPONSE TO CENTRAL OSMOTIC STIMULATION[J]. Acta Physiologica Sinica, 1991, 43(1): 94-97 |
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| Authors: | LUO YONG ZHANG QI |
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| Affiliation: | Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | In order to study the mechanism of pressor response to central osmotic stimula-tion,rats were administered with hypertonic artificial cerebrospinal fluid(ACSF)intracerebroventricularly.Carotid arterial pressure and heart rate were recorded.Ten minutes after administration,blood samples,hypothalamus and hypophysiswere taken for the determination of atrial natriuretic peptide(ANP)and vasopressin(AVP)by radioimmunoassay.The results showed that after central administrationof hypertonic ACSF,the plasma level of AVP increased significantly with no apparentchange in ANP.In hypothalamus and hypophysis,the content of ANP was increasedwhile that of AVP decreased. |
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| Keywords: | atrial natriuretic peptide vasopressin intracerebroventricular administration central o(?)moreceptor rat |
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