Feeding strategy for the production of the new antibiotic myxovirescin A from Myxococcus virescens (Myxobacterales)

Summary Myxovirescin A is a new antibiotic from Myxococcus virescens. Conditions of growth on peptone media result in the antibiotic being secreted during the transition to the stationary phase. When growth is exponential, no detectable production occurs.In an attempt to improve production of the antibiotic, peptone was fed to the peptone-limited culture at differing feed rates. Product formation was found to be dependent on the peptone supply, and the product concentration could be improved from 0.04 to 2 mg/l myxovirescin A.Article No. 13 on antibiotics from gliding bacteria Article No. 12: Thierbach G, Reichenbach H (1983). The effect of the new antibiotic myxothiazol on the respiration of Paracoccus denitrificans. Arch Microbiol 134: 104–107