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Computational methods for the design of effective therapies against drug resistant HIV strains |
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| Authors: | Beerenwinkel Niko Sing Tobias Lengauer Thomas Rahnenführer Jörg Roomp Kirsten Savenkov Igor Fischer Roman Hoffmann Daniel Selbig Joachim Korn Klaus Walter Hauke Berg Thomas Braun Patrick Fätkenheuer Gerd Oette Mark Rockstroh Jürgen Kupfer Bernd Kaiser Rolf Däumer Martin |
| Institution: | Department of Mathematics, University of California, Berkeley, CA, USA. niko@math.berkeley.edu |
| Abstract: | The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data. |
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