Koenoline,a further cytotoxic carbazole alkaloid from Murraya koenigii |
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| Authors: | Manfred Fiebig John M. Pezzuto Djaja D. Soejarto A.Douglas Kinghorn |
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| Affiliation: | Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Health Sciences Center, University of Illinois at Chicago, Chicago, IL 60612, U.S.A. |
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| Abstract: | Koenoline, a carbazole alkaloid, has been isolated from the root bark of Murraya koenigii for the first time as a natural product. Its structure was established as 1-methoxy-3-hydroxymethylcarbazole by analysis of spectroscopic data and was confirmed by partial synthesis from murrayanine isolated from M. siamensis roots. Koenoline exhibited cytotoxic activity against the KB cell-culture test system. |
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| Keywords: | M. siamensis Rutaceae carbazole alkaloids koenoline 1-methoxy-3-hydroxymethylcarbazole murrayanine cytotoxic activity. |
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