| 蕈样肉芽肿与扁平苔藓、慢性皮炎湿疹浸润细胞的免疫组化比较研究 |
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| 引用本文： | 郭英军,赵玉铭,陈洪铎,冯林. 蕈样肉芽肿与扁平苔藓、慢性皮炎湿疹浸润细胞的免疫组化比较研究[J]. 中国组织化学与细胞化学杂志, 2008, 17(3). DOI: 10.3870/j.issn.1004-1850.2008.03.004 |
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| 作者姓名： | 郭英军 赵玉铭 陈洪铎 冯林 |
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| 作者单位： | 1. 中国医科大学附属第一医院,皮肤科沈阳,110001
2. 中国医科大学附属盛京医院皮肤科,沈阳,110004 |
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| 摘 要： | 目的探讨免疫表型对蕈样肉芽肿与扁平苔藓、慢性皮炎湿疹鉴别诊断的意义。方法本研究应用ABC免疫组化技术检测15例蕈样肉芽肿,17例慢性皮炎湿疹,17例扁平苔藓,6例正常皮肤的CD1a、CD8、ICAM-1和CD7的表达情况。结果1.蕈样肉芽肿表皮CD1a,CD8,ICAM-1的阳性细胞密度明显高于扁平苔藓、皮炎湿疹和正常皮肤。2.蕈样肉芽肿真皮中CD1a阳性细胞的线性密度高于扁平苔藓、慢性皮炎湿疹和正常皮肤,蕈样肉芽肿真皮内CD8阳性细胞百分比较慢性皮炎湿疹增多,蕈样肉芽肿真皮表达ICAM-1抗原的细胞百分比高于扁平苔癣和慢性皮炎湿疹。3.慢性皮炎湿疹、扁平苔藓真皮内CD7阳性细胞百分比高于蕈样肉芽肿和正常皮肤。结论CD1a、CD8、ICAM-1、CD7免疫表型的研究可能为蕈样肉芽肿和扁平苔藓、慢性皮炎湿疹等一些炎症性皮肤病的鉴别诊断提供一定的线索。
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| 关 键 词： | 蕈样肉芽肿 扁平苔藓 皮炎湿疹 免疫表型 |
COMPARATIVE ANALYSIS OF IMMUOHISTOLOGICAL FEATURES AMONG MYCOSIS FUNGOIDES,LICHEN PLANUS AND ECZEMATOUS DERMATITIS |
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| Guo Yingjun,Zhao Yuming,Chen Hongduo,Feng lin. COMPARATIVE ANALYSIS OF IMMUOHISTOLOGICAL FEATURES AMONG MYCOSIS FUNGOIDES,LICHEN PLANUS AND ECZEMATOUS DERMATITIS[J]. Chinese Journal of Histochemistry and Cytochemistry, 2008, 17(3). DOI: 10.3870/j.issn.1004-1850.2008.03.004 |
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| Authors: | Guo Yingjun Zhao Yuming Chen Hongduo Feng lin |
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| Affiliation: | Guo Yingjun1,Zhao Yuming,Chen Hongduo,Feng lin1(Department of Dermatiology,the First Affiliated Hospital,Department of Dermatology,Shengjing Hospital,Chna Medical University,Shengyang 110004,China) |
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| Abstract: | Objective To evaluate the role of immunophenotyping as an adjunct to the histopathological diagnosis of mycosis fungoides(MF).Methods 15 cases of MF,17 lichen planus,17 eczematous dermatitis and 6 healthy controls were included in this study.Cryosections were stained for ICAM-1(infiltrating cells and dendritic cells),CD8,CD1a and CD7 monoclonal antibodies.Results 1.In the epidermis of MF,the density of CD1a,CD8 and ICAM-1 were higher than in lichen planus,eczematous dermatitis and healthy controls.2.In the ... |
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| Keywords: | Mycosis fungoides Lichen planus Eczematous dermatitis Immunophenotyping |
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