Arylpiperazine substituted heterocycles as selective alpha(1a) adrenergic antagonists |
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| Authors: | Khatuya Haripada Hutchings Richard H Kuo Gee-Hong Pulito Virginia L Jolliffe Linda K Li Xiaobing Murray William V |
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| Institution: | Drug Discovery Research, Johnson & Johnson Pharmaceutical Research and Development LLC, Raritan, NJ 08869, USA. |
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| Abstract: | Antagonists of the alpha(1)-adrenergic receptors (alpha(1)-ARs) are useful for the treatment of benign prostatic hyperplasia. A series of potent and subtype-selective alpha(1a)-AR antagonists has been synthesized, displaying in vitro binding affinity in the low the nanomolar range. |
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