Molecular screening of interleukin-6 gene promoter and influence of −174G/C polymorphism on breast cancer |
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Authors: | Michel Chrel Loïc Campion Stphane Bzieau Mario Campone Josiane Charrier Joëlle Gaschet Gabriel Ricolleau Wilfried Gouraud Catherine Charbonnel Pascal Jzquel |
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Institution: | Michel Chérel, Loïc Campion, Stéphane Bézieau, Mario Campone, Josiane Charrier, Joëlle Gaschet, Gabriel Ricolleau, Wilfried Gouraud, Catherine Charbonnel,Pascal Jézéquel, |
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Abstract: | Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including carcinogenesis. In 2003, a single nucleotide polymorphism (−174G/C) of the IL-6 gene promoter has been linked to breast cancer prognosis in node-positive (N+) breast cancer patients. Since, different studies have led to conflicting conclusions about its role as a prognostic and/or diagnostic marker. The primary aim of our study was to investigate the link between −174G/C polymorphism and breast cancer risk on the one hand, and −174G/C polymorphism and prognosis in different groups of patients: sporadic N+ breast cancers (n = 138), sporadic N− breast cancers (n = 95) and familial breast cancer (n = 60) on the other hand. The variables of interest were disease-free survival and overall survival. The secondary aim of the study was to screen IL-6 gene promoter using direct sequencing to identify new polymorphisms in our French Caucasian breast cancer population. No association or trend of association between −174G/C polymorphism of IL-6 gene promoter gene and breast cancer diagnosis or prognosis was shown, even in meta-analyses. Furthermore, we have identified four novel polymorphic sites in the IL-6 gene promoter region: −764G → A, −757C → T, −233T → A, 15C → A. |
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Keywords: | Breast cancer Interleukin-6 promoter Polymorphism Prognostic Sequencing |
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