Changes in renal efferent activity and autonomic response to GABA applied to structures of the ventrolateral surface of the cat medulla oblongata

Effects of injecting 1 µl 1·10^–5–5·10^–4 M gamma-aminobutyric acid (GABA) into the neuronal structures of the chemically sensitive area of the bulbar ventrolateral surface and clearly-defined borders of this area with GABA-sensitive cells were investigated in cats anesthetized by a mixture of chloralose and urethane. It was found that GABA, interacting with bicuculline-sensitive GABA_a receptors, exercises an inhibitory effect on the activity of neuronal structures of the ventrolateral surface involved in governing blood pressure, heart rate, and vascular tonus.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 19, No. 3, pp. 327–334, May–June, 1987.