Insulin-, glucagonand somatostatin-like immunoreactivity in the endocrine pancreas of the lungfish,Neoceratodus forsteri |
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| Authors: | Dr. Georg Nørgaard Hansen Bente Langvad Hansen Peer Nobert Jørgensen |
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| Affiliation: | (1) Institute of Cell Biology and Anatomy, University of Copenhagen, Denmark;(2) Institute of Medical Microbiology, University of Copenhagen, Denmark;(3) Monoclonal Antibody Laboratory, Novo BioLabs, Bagsværd, Denmark;(4) Institute of Cell Biology and Anatomy, University of Copenhagen, 15 Universitetsparken, DK-2100 Copenhagen Ø, Denmark |
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| Abstract: | Summary The endocrine pancreas of the Australian lungfish,Neoceratodus forsteri, was investigated immunocytochemically for the presence of polypeptide hormone-producing cells. Three cell types were identified, namely insulin-, glucagon-, and somatostatin-immunoreactive elements. The insulin cells are confined solely to the center of the islets. Glucagon and somatostatin cells are distributed peripherally around the central mass of the insulin cells. Isolated cells or clusters of glucagon and somatostatin cells are also dispersed within the exocrine parenchyma. The immunoreactive cell types are compared with those staining with standard histological procedures. The spatial relationships of the different cell populations are examined. |
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| Keywords: | Endocrine pancreas Insulin Glucagon Somatostatin Immunocytochemistry Neoceratodus forsteri (Australian lungfish) |
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