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| 慢性阻塞性肺疾病急性加重期病原学及细菌药性分析 | |
| 引用本文： | 高健,孙圣华,苏洽光.慢性阻塞性肺疾病急性加重期病原学及细菌药性分析[J].现代生物医学进展,2010,10(2). |
| 作者姓名： | 高健 孙圣华 苏洽光 |
| 作者单位： | 1. 湘西自治州人民医院呼吸内科,湖南,湘西自治州,416000 2. 中南大学湘雅三医院呼吸内科 3. 中山市第二人民医院ICU,广东,广州 |
| 摘 要： | 目的:探讨慢性阻塞性肺疾病急性加重期病原学特点及细菌耐药情况,为临床合理使用抗生素提供科学依据。方法:回顾性分析我院呼吸内科和老年学科2008年1月-2009年1月563例慢性阻塞性肺疾病(急性加重期)住院患者痰培养及药敏试验结果。结果:563例患者中检出阳性结果205例,检出率为36.41%。其中G+菌46例、G-菌119例、真菌40例。G+菌以金黄色葡萄球菌最多(14例),其次为表皮葡萄球菌和草绿色链球菌;G-菌以铜绿假单胞菌最多(37例),其次为克雷伯菌;真菌以白色念珠菌最多(20例)。G-杆菌对氨苄西林、哌拉西林、头孢唑啉、复方新诺明耐药严重,对亚胺培南、含β-内酰胺酶抑制剂的联合制剂较敏感。金黄色葡萄球菌对多种抗生素严重耐药,对万古霉素、亚胺培南较敏感。真菌对氟康唑敏感占50.81%,对伊曲康唑敏感占30.12%,对酮康唑敏感占30.83%,对5-氟胞嘧啶敏感占10.74%。结论:慢性阻塞性肺疾病急性加重期以G-为主,真菌感染有增多趋势,病原菌呈现多重耐药现象。 |
| 关 键 词： | 慢性阻塞性肺疾病 病原菌 耐药性 |
Etiology and drug resistance analysis in acute exacerbation of chronic obstructive pulmonary disease |
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| GAO Jian,SUN Sheng-hua,SU Qia-guang.Etiology and drug resistance analysis in acute exacerbation of chronic obstructive pulmonary disease[J].Progress in Modern Biomedicine,2010,10(2). | |
| Authors: | GAO Jian SUN Sheng-hua SU Qia-guang |
| Institution: | GAO Jian1,SUN Sheng-hua2,SHU Qia-guang2(1 Department of geriatric medicine,Xiangxi Autonomous Prefecture People\'s Hospital,Jishou 416000,Hunan,China,2 Department of Respiratory Diseases,the third Xiangya Hospital,Central South University,Changsha 410013,China) |
| Abstract: | Objective:To study the characteristics of the etiology and drug resistance in acute exacerbation of chronic obstructive pulmonary disease patients,to provide a favorable clinical basis for rational drug use. Methods:563 cases diagnosed as AECOPD patients from January 2008 to January 2009 in Respiratory and Geriatric Medicine departments at our hospital were retrospectively analyzed. Results:of their sputum samples for culture and sensitivity test were collected and analyzed. Results 205 cases(36.41%) out of... |
| Keywords: | Chronic obstructive pulmonary disease Etiology Drug resistance |
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