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Discovery of phage determinants that confer sensitivity to bacterial immune systems
Affiliation:1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel;1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA;3. Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;4. Division of Biology, Kansas State University, Manhattan, KS, USA;5. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA;6. Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;7. Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA;8. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;9. Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA;10. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;11. Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA;12. Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;13. Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA;1. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;4. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;5. Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;6. Cardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;1. Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany;2. Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;3. Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany;1. State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China;2. Changping Laboratory, Beijing 102206, China;3. Changping Laboratory Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;4. MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;5. National Institute of Biological Sciences, Beijing 102206, China;6. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China;7. National Biomedical Imaging Center, Peking University, Beijing 100871, China;1. Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA;2. Bioinformatics Service, Department of Health Sciences Libraries, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA;3. Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA;4. University of Southern California, School of Pharmacy, Los Angeles, CA 90033, USA;1. Synthetic Biology Group, Microbiology Department, Institut Pasteur, Paris 75015, France;2. Institute of Molecular and Supramolecular Chemistry and Biochemistry, University of Lyon-CNRS, Villeurbanne 69100, France;3. AgroParisTech, Paris 75005, France;4. Laboratory of Bacteriology, Rockefeller University, New York, NY 10065, USA;5. Proteomics Resource Center, Rockefeller University, New York, NY 10065, USA
Abstract:
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  • Keywords:anti-phage  Ec48  Eco8  Ec67  retron  msDNA  RecBCD  abortive infection  bacterial defense  bacterial immunity  phage resistance  phage triggers  phage sensitivity determinants  phage escape  escaper phages
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