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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
Affiliation:1. Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA;2. Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA;3. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland;4. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;5. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;6. Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;7. Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA;8. Department of Informatics, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA;9. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA;10. Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA;11. Department of Medicine and Graduate Schools, Weill Cornell Medicine, New York, NY, USA;1. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;4. James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;5. MD Anderson UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;7. Department of Head & Neck Surgery Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;8. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;1. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA;2. Department of Molecular and Cell Biology, University of California Berkeley, CA 94720, USA;3. Zealand Pharma A/S, Sydmarken 11, Soborg 2860, Denmark;4. QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA;5. Department of Chemistry, University of California, Berkeley, Berkeley CA 94720, USA;6. Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, Marburg 35037, Germany;7. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA;1. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;2. Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA;5. Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;6. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA;7. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI, USA;8. Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;9. BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA;1. Columbia Center for Translational Immunology, Irving Medical Center, New York, NY, USA;2. Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA;3. Department of Hematology Oncology, Columbia University Irving Medical Center, New York, NY, USA;4. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;6. Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;7. Department of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA;8. J.P. Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA;9. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA;10. Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA;11. Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA;12. Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA;13. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;14. Department of Pathology, UNC School of Medicine, Chapel Hill, NC, USA;1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;1. Division of Tumor Biology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands
Abstract:
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  • Keywords:immunotherapy  neutrophils  OX40  adoptive T cell therapies  anti-tumor neutrophils  immune checkpoint blockade  CTLA-4  neutrophil extracellular traps  tumor hetergeneity  antigenic heterogeneity
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