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Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
Affiliation:1. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;2. Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA;5. Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;6. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA;7. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI, USA;8. Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;9. BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA;1. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA;2. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA;3. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA;1. Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA;1. Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Department of Medicine, Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Department of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;5. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;6. Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA;7. Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA;8. Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA;9. Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA;10. Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA;11. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA;12. Department of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, Canada;13. Division of Pediatric Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA;1. College of Life Sciences, Peking University, Beijing 100871, China;2. National Institute of Biological Sciences, Beijing 102206, China;3. College of Life Sciences, Tsinghua University, Beijing 100084, China;4. College of Life Sciences, Beijing Normal University, Beijing 100875, China;5. Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, 200031, China;6. CAS Center for Excellence in Molecular Cell Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, 200031, China;7. Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, 200031, China;8. School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China;9. Institute of Biomechanics and Medical Engineering, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China;1. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA;2. Department of Molecular and Cell Biology, University of California Berkeley, CA 94720, USA;3. Zealand Pharma A/S, Sydmarken 11, Soborg 2860, Denmark;4. QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA;5. Department of Chemistry, University of California, Berkeley, Berkeley CA 94720, USA;6. Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, Marburg 35037, Germany;7. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA;1. Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia;2. St Vincent’s Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia;3. MRC Human Immunology Unit, Nuffield Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK;4. Department of Biology and Biochemistry, University of Bath, Bath, UK;5. Département de Biologie, Université de Lyon, Lyon, France;6. EMBL Australia, Single Molecule Science Node, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia;7. Department of Systems Biology and Braunschweig Integrated Center for Systems Biology (BRICS), Helmholtz Center for Infection Research, Rebenring 56, D-38106 Braunschweig, Germany;8. Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany;9. Centenary Institute and University of Sydney, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia;10. Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan;11. Mater Research Institute, University of Queensland, Brisbane, QLD, Australia
Abstract:
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  • Keywords:biophysical forces  mechanotransduction  lung  alveolar epithelial cell  lamina-associated domain
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