首页 | 本学科首页   官方微博 | 高级检索  
     


Negative allosteric modulation of the glucagon receptor by RAMP2
Affiliation:1. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA;2. Department of Molecular and Cell Biology, University of California Berkeley, CA 94720, USA;3. Zealand Pharma A/S, Sydmarken 11, Soborg 2860, Denmark;4. QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA;5. Department of Chemistry, University of California, Berkeley, Berkeley CA 94720, USA;6. Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, Marburg 35037, Germany;7. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA;1. Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA;1. Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland;2. Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, 2000 Neuchâtel, Switzerland;1. Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;2. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA;3. Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA;4. Aaron Diamond AIDS Research Center, Columbia University, New York, NY 10032, USA;5. Department of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016, USA;6. Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;7. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA;8. Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA;9. Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;10. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA;11. Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;12. Columbia University George M. O’Brien Urology Center, New York, NY 10032, USA;1. Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Department of Medicine, Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Department of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;5. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;6. Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA;7. Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA;8. Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA;9. Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA;10. Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA;11. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA;12. Department of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, Canada;13. Division of Pediatric Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA;1. Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA;2. Department of Systems Biology, Harvard Medical School, Boston, MA, USA;3. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;4. AGORA Cancer Research Center, Lausanne, Switzerland;5. Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands;6. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA;7. Service of Medical Oncology, Department of Oncology, CHUV, Lausanne, Switzerland;8. Department of Oncology, University of Lausanne, Lausanne, Switzerland;9. Ludwig Institute for Cancer Research, Lausanne, Switzerland;10. Department of Oncology, CHUV, Lausanne, Switzerland;11. Swiss Cancer Center Leman, Lausanne, Switzerland;1. Laboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA
Abstract:
><ol class=
  • Download : Download high-res image (232KB)
  • Download : Download full-size image
  • Keywords:G-protein coupled receptor  GPCR  G-protein  glucagon receptor  receptor activity-modifying protein RAMP  cryo-electron microscopy  cryo-EM  single molecule fluorescence resonance energy transfer  smFRET  hydrogen-deuterium exchange monitored by mass spectrometry  HDX-MS  allostery  protein dynamics  cell signaling
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号