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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Affiliation:1. Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada;2. Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada;3. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;4. Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;5. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA;6. Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada;7. Division of Orthopedic Surgery, Faculty of Surgery, McGill University, Montreal, QC H3G 1A4, Canada;8. Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada;9. Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada;10. Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA;11. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA;12. Marine College, Shandong University, Weihai 264209, China;13. Department of Biochemistry and Molecular Medicine, Université de Montreal, Research Center of the CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada;14. Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada;15. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada;16. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;17. Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Canada;18. Child Health and Human Development, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada;19. Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;20. McGill Integrated Core for Animal Modeling (MICAM), McGill University, Montreal, QC, Canada;21. Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada;22. Department of Pathology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada;23. Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany;24. Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;25. Institute of Human Genetics, University Hospital of the Paracelsus Medical University Salzburg, Salzburg, Austria;26. Division of Medical Genetics, Duke University Hospital, Durham, NC, USA;27. Division of Pediatric Neurology, Duke University Hospital, Durham, NC, USA;28. Department of Pediatrics, Duke University Hospital, Durham, NC, USA;29. Children’s Hospital of Philadelphia, Philadelphia, PA, USA;1. State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Department of Neurology, the First Affiliated Hospital of Xiamen University, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361005, China;2. Shenzhen Research Institute of Xiamen University, Shenzhen, Guangdong 518057, China;3. Department of Functional Neurosurgery, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, Fujian 361003, China;4. National Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China;5. United Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen 361103, China;6. State Key Laboratory of Cellular Stress Biology, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361005, China;7. Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA;8. Center for Brain Sciences, the First Affiliated Hospital of Xiamen University, Institute of Neuroscience, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Xiamen University, Xiamen, Fujian 361005, China;9. Institute for Brain Science and Disease, Chongqing Medical University, Chongqing 400016, China;1. Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA;1. Department of Medicine, Division of Hematology & Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA;2. Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA;3. Department of Microbiology and Immunology, Pediatrics and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA;4. Family Health International 360, Durham, NC 27761, USA;5. Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA;6. StemCyte International Cord Blood Center, Baldwin Park, CA 91706, USA;7. Department of Pediatrics, Division of Hematology& Oncology, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA;8. Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA;9. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;10. Department of Pediatrics, Division of Infectious Diseases, Mattel Children’s, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;11. Frontier Science & Technology Research Foundation, Inc, Amherst, NY 14226, USA;12. Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin Clinical Cancer Center, Milwaukee, WI 53226, USA;13. Department of Medicine, Division of Infectious Diseases, University of Pittsburg School of Medicine, Pittsburgh, PA 15261, USA;14. National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA;15. IMPAACT Operations Center, FHI 360, 359 Blackwell St, Ste 200, Durham, NC 27701, USA;1. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA;2. Department of Neurobiology, Stanford University, Stanford, CA 94305, USA;3. Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA;4. Department of Biology, Stanford University, Stanford, CA 94305, USA;5. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA;6. Champalimaud Neuroscience Program, Champalimaud Center for the Unknown, 1400-038 Lisbon, Portugal;7. Department of Psychiatry, Erasmus MC University Medical Center, 3015 GD Rotterdam, the Netherlands;1. QB3-Berkeley, Berkeley, CA, USA;2. Biophysics Graduate Group, University of California Berkeley, Berkeley, CA, USA;3. Department of Chemistry, University of California Berkeley, Berkeley, CA, USA;4. Department of Physics, University of California Berkeley, Berkeley, CA, USA;5. Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA;6. Kavli Energy Nanoscience Institute, Berkeley, CA, USA;7. Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA;8. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA;1. Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. Peking-Tsinghua Center for Life Sciences, Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;3. Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;4. Shenzhen Bay Laboratory, Shenzhen 518055, China;5. Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China;6. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China
Abstract:
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  • Keywords:H3.3 G34R/V/W  neurodegeneration  H3K36me2  DNMT3A  CH methylation  oncohistones  complement  DNA methylation  synaptic pruning  neuroinflammation
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