The effect of ventromedial hypothalamic nuclei destruction on somatostatin and insulin release from the isolated perfused rat pancreas |
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| Authors: | S Seino Y Seino H Sakurai J Takemura H Kuzuya H Imura K Ishikawa T Shimazu M Usami M Ikeda |
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| Affiliation: | 1. Second Division of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan;1. Division of Neurochemistry, Psychiatric Research Institute of Tokyo, Tokyo, Japan;7. Diabetes Center, Ikeda Clinic, Amagasaki, Japan |
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| Abstract: | The effect of electrolytic lesions in the ventromedial hypothalamic nuclei (VMH) on somatostatin and insulin release was studied using the isolated perfused rat pancreas. Obesity gradually developed in the rats after placement of the VMH lesions, and fasting insulin levels determined immediately before the isolation of the pancreas were significantly higher than those in sham-operated controls. In the presence of 4.4 mM glucose, both perfusate somatostatin and insulin responses to arginine were significantly greater than in the controls, suggesting that VMH lesions cause not only hypersecretion of insulin but hypersecretion of somatostatin as well. |
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