Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis |
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| Authors: | Priyabrata Mukherjee Resham Bhattacharya Nancy Bone Yean K Lee Chitta Ranjan Patra Shanfeng Wang Lichun Lu Charla Secreto Pataki C Banerjee Michael J Yaszemski Neil E Kay Debabrata Mukhopadhyay |
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| Affiliation: | (1) Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir William-Osler, McIntyre Medical Sciences Building, Montreal, QC, H3G 1Y6, Canada;(2) Faculty of Pharmacy and Department of Chemistry, University of Montreal, Pavillon J. A. Bombardier, C.P. 6128 Succursale Centre-Ville, Montreal, QC, H3C 3J7, Canada;(3) Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada |
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| Abstract: | Background Neuroblastoma, a frequently occurring solid tumour in children, remains a therapeutic challenge as existing imaging tools are inadequate for proper and accurate diagnosis, resulting in treatment failures. Nanoparticles have recently been introduced to the field of cancer research and promise remarkable improvements in diagnostics, targeting and drug delivery. Among these nanoparticles, quantum dots (QDs) are highly appealing due to their manipulatable surfaces, yielding multifunctional QDs applicable in different biological models. The biocompatibility of these QDs, however, remains questionable. |
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