Identification and characterization of bovine regulator of telomere length elongation helicase gene (<Emphasis Type="Italic">RTEL</Emphasis>): molecular cloning,expression distribution,splice variants and DNA methylation profile |
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| Authors: | Zhuo Du DingSheng Zhao YongHui Zhao ShaoHua Wang Yu Gao Ning Li |
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| Institution: | (1) State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, 10094, China;(2) Institute of Space Medico-Engineering, Beijing, 100094, China;(3) Faculty of life science, Liaoning University, Shenyang, 110036, China;(4) College of Animal Science and Technology, China Agricultural University, Beijing, 10094, China |
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| Abstract: | Background The genetic basis of telomere length heterogeneity among mammalian species is still not well understood. Recently, a gene
named regulator of telomere length elongation helicase (RTEL) was identified and predicted to be an essential participant in species-specific telomere length regulation in two murine
species. To obtain broader insights into its structure and biological functions and to ascertain whether RTEL is also a candidate gene in the regulation of telomere length diversity in other mammalian species, data from other mammals
may be helpful. |
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