| 错位双链核糖核酸的热原反应 |
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| 引用本文： | 聂实践,胡冬琴.错位双链核糖核酸的热原反应[J].中国生物工程杂志,2003,23(2):97-100. |
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| 作者姓名： | 聂实践 胡冬琴 |
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| 作者单位： | 1. 天津科技大学生物工程学院 天津 300222;
2. 北京百林康源生物技术公司 北京 100054 |
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| 摘 要： | 由于错位dsRNA的毒副作用得到降低,因此是一类很有潜力的抗病毒、抗肿瘤物质。研究中利用家兔实验评价了PolyI:C和PolyI:C12U引起的热原反应。在10mgml、1mgml、005mgml剂量水平PolyI:C12U均未产生发热和其他毒副作用,而PolyI:C实验组均有发热现象,甚至有家兔死亡。
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| 关 键 词： | 错位双链核糖核酸 热原反应 dsRNA 抗病毒作用 抗肿瘤作用 |
Research on the Pyrogenic Effect in Rabbit Caused by Double Stranded RNA |
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| Nie Shijian,Hu Dongqin.Research on the Pyrogenic Effect in Rabbit Caused by Double Stranded RNA[J].China Biotechnology,2003,23(2):97-100. |
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| Authors: | Nie Shijian Hu Dongqin |
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| Institution: | 1 Tianjin University of Science and Technology Tianjin 300222 2 Brins |Live Pro Biotechnology Co.LTD Beijing 100054 |
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| Abstract: | Mismatched double stranded RNA is one of the potential materials for anti-tumor and anti-virus because the mismatched base pair structure prominently reduce the toxic side effects.The pyrogenic effects in rabbit caused by double stranded RNA (Poly I:C) and its mismatched analogues (Poly I:C 12 U) were tested.Poly I:C 12 U have not appeared any toxicity and other side effect,but Poly I:C caused rabbit fever and even death. ; |
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| Keywords: | Double stranded RNA Pyrogenic effects |
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