Changes inγ-aminobutyric acid during different stages of picrotoxin-induced seizure,and the effect of pretreatment withγ-acetylenic GABA and phenobarbital |
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Authors: | Abdul-Salam Abdul-Ghani |
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Institution: | (1) Department of Biology and Biochemistry, Faculty of Science, Birzeit University, Birzeit, West Bank, Palestine |
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Abstract: | Changes in GABA content of various brain areas during different stages of picrotoxin-induced seizures and following pretreatment
with the anti-convulsants phenobarbital andγ-acetylenic GABA were studied. Picrotoxin (6mg/kg) produced clonic/tonic convulsions associated with a 34% reduction in GABA
content of the sensory motor cortex. A reduction of 24% was observed 1 min before the onset of seizure and the reduction in
GABA content was reversible 20 min after the convulsion. No significant changes were observed in the cerebellum or spinal
cord/medulla oblongata. Pretreatment with phenobarbital (100mg/kg) delayed the onset of convulsion and decreased the mortality
rate without causing any change in GABA content at the pre-convulsive, convulsive or post-convulsive stages.γ-Acetylenic GABA (100mg/kg) has elevated GABA levels in different areas of the brain by 2–3-fold after 60 min treatment. This
increase was reduced by 44% during the onset of picrotoxin-induced seizures. Picrotoxin convulsion can occur in the presence
of normal, reduced or even elevated brain GABA content. The only consistent factor is a one-third reduction in GABA content
before the onset of seizure. |
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Keywords: | GABA γ -acetylenic GABA picrotoxin phenobarbital |
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