A new computational method to split large biochemical networks into coherent subnets |
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Authors: | Wynand S Verwoerd |
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Institution: | (1) Centre for Advanced Computational Solutions, Dept WF & Molecular Bioscience, Lincoln University, Ellesmere Junction Road, Christchurch, New Zealand |
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Abstract: | Background Compared to more general networks, biochemical networks have some special features: while generally sparse, there are a small
number of highly connected metabolite nodes; and metabolite nodes can also be divided into two classes: internal nodes with
associated mass balance constraints and external ones without. Based on these features, reclassifying selected internal nodes
(separators) to external ones can be used to divide a large complex metabolic network into simpler subnetworks. Selection
of separators based on node connectivity is commonly used but affords little detailed control and tends to produce excessive
fragmentation. |
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Keywords: | |
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