Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck |
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| Authors: | Calderwood David J Johnston David N Munschauer Rainer Rafferty Paul |
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| Affiliation: | Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA. david.calderwood@abbott.com |
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| Abstract: | A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing. |
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