Effects of x-irradiation on lipide metabolism. II. Uptake of P32 into rat liver phospholipides |
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| Authors: | ENTENMAN C LERNER S R WEINMAN E O |
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| Affiliation: | 1. West Virginia University School of Medicine, Morgantown, WV 26506, United States of America;2. West Virginia Clinical and Translational Science Institute, Morgantown, WV 26506, United States of America;3. West Virginia Board of Pharmacy, 2310 Kanawha Blvd, Charleston, WV 25311, United States of America;4. West Virginia University School of Public Health, Department of Epidemiology, Morgantown, WV 26506, United States of America |
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| Abstract: | - 1.1. The effect of whole-body x-irradiation on the incorporation of inorganic P32 into phospholipides of rat liver and liver cell fractions were studied both in vitro and in vivo.
- 2.2. Liver slices from rats, 24 hr. after exposure to 1000 or 2500 r., incorporated more P32 into phospholipides than did slices from unirradiated rats. Increased incorporation also occurred in the various cell fractions studied, namely nuclei, mitochondria, microsomes, and supernatant.
- 3.3. No increase in P32 incorporation into phospholipides of the liver or liver cell fractions was noted in rats which were injected with inorganic P32 24 hr. after irradiation with 2500 r.
- 4.4. The significance of these results is discussed and possible explanations are proposed for the differences between the in vitro and in vivo findings.
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