Role of vasoactive intestinal polypeptide (VIP) in regulating the pituitary function in man |
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Authors: | Y Kato A Shimatsu N Matsushita H Ohta H Imura |
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Institution: | Second Medical Clinic, Department of Medicine, Kyoto University, Faculty of Medicine 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan |
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Abstract: | Intramuscular injection of synthetic VIP (200 micrograms) resulted in a rapid increase in plasma prolactin (PRL) concentrations in normal women, which was accompanied by the 4- to 7-fold increase in plasma VIP levels. Mean (+/- SE) peak values of plasma PRL obtained 15 min after the injection of VIP were higher than those of saline control (28.1 +/- 6.7 ng/ml vs. 11.4 +/- 1.6 ng/ml, p less than 0.05). Plasma growth hormone (GH) and cortisol levels were not affected by VIP in normal subjects. VIP injection raised plasma PRL levels (greater than 120% of the basal value) in all of 5 patients with prolactinoma. In 3 of 8 acromegalic patients, plasma GH was increased (greater than 150% of the basal value) by VIP injection. In the in vitro experiments, VIP (10(-8), 10(-7) and 10(-6) M) stimulated PRL release in a dose-related manner from the superfused pituitary adenoma cells obtained from two patients with prolactinoma. VIP-induced GH release from the superfused pituitary adenoma cells was also shown in 5 out of 6 acromegalic patients. VIP concentrations in the CSF were increased in most patients with hyperprolactinemia and a few cases with acromegaly. These findings indicate that VIP may play a role in regulating PRL secretion in man and may affect GH secretion from pituitary adenoma in acromegaly. |
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Keywords: | Vasoactive intestinal polypeptide (VIP) Growth hormone (GH) Prolactin (PRL) TRH Acromegaly Prolactinoma Cerebrospinal fluid (CSF) Superfusion LHRH |
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