Positions of double bonds in the monounsaturated alk-1-enyl groups from the plasmalogens of human heart and brain |
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| Authors: | R V Panganamala L A Horrocks J C Geer D G Cornwell |
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| Affiliation: | 1. Biomedical Lab Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA;2. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA;3. VA Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA;4. Division of Human Nutrition and Health, Wageningen University, The Netherlands |
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| Abstract: | The phospholipids of human heart were found to include 16.3 per cent alk-1-enyl acyl glycerophosphorylcholines and 14.9 per cent alk-1-enyl acyl glycerophosphorylethanolamines. A sample of human brain with both gray and white matter contained 0.9 per cent of the former and 22.4 per cent of the latter. Alkyl-1,3-dioxolane derivatives of the alk-1-enyl groups were prepared. The octadecenyl dioxolanes accounted for 18 per cent of the choline plasmalogens and 23 per cent of the ethanolamine plasmalogens from heart and 43 per cent of the ethanolamine plasmalogens from brain. The 18:1 dioxolanes from the heart plasmalogens had a 64:36 distribution of 9,10 and 11,12 double bonds whereas the corresponding value was 30:70 for the brain plasmalogens. |
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