The role of intrahepatic gammadelta-T cells for liver injury induced by Salmonella infection in mouse. |
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Authors: | M Ishigami H Nishimura K Yoshioka S Kakumu Y Yoshikai |
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Institution: | Research Institute for Disease Mechanism and Control, and Third Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan. |
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Abstract: | Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-delta knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (UC7-13D5) to stimulate gammadelta-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that gammadelta-T cells have effector activities not only for protection but also for liver injury during Salmonella infection. |
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Keywords: | γδ-T cells liver injury salmonella |
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