Genetic markers of osteoarticular disorders: facts and hopes |
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Authors: | Maria Luisa Brandi Luigi Gennari Marco Matucci Cerinic Lucia Becherini Alberto Falchetti Laura Masi Carlo Gennari Jean-Yves Reginster |
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Institution: | (1) Department of Medicine, University of Florence, Florence, Italy;(2) Section of Rheumatology, University of Florence, Florence, Italy;(3) Institute of Internal Medicine, University of Siena, Siena, Italy;(4) Bone and Articular Cartilage Research Unit, University of Liege, Belgium |
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Abstract: | Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing
a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders
have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders
are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may
provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting
the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history
of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent
work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation
of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches. |
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Keywords: | candidate genes genetics multifactorial diseases osteoporosis osteoarthritis |
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