Reverse gyrase: an insight into the role of DNA-topoisomerases |
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Authors: | Nadal Marc |
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Affiliation: | Equipe Virologie Moléculaire et Microbiologie, Laboratoire de Génétique et de Biologie Cellulaire, CNRS UMR 8159, Université de Versailles St-Quentin-en-Yvelines, Batiment Buffon, 78 035 Versailles, France. marc.nadal@igmors.u-psud.fr |
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Abstract: | Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability. |
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