首页 | 本学科首页   官方微博 | 高级检索  
     

LIGHT与疾病的关系研究现状
引用本文:徐莎,陈丽丽. LIGHT与疾病的关系研究现状[J]. 微生物学免疫学进展, 2013, 0(6): 66-70
作者姓名:徐莎  陈丽丽
作者单位:南华大学公共卫生学院卫生检验系,湖南衡阳421001
基金项目:国家自然科学基金青年科学基金项目(81001318),湖南省教育厅优秀青年项目(138099)
摘    要:LIGHT/TNFSF14是肿瘤坏死因子超家族第14个成员,能够与HVEM和LTβSR结合,调节免疫系统功能,并参与多种生理病理过程。近年来大量研究表明,LIGHT及其信号通路与多种自身免疫病、移植物抗宿主病、病原体感染以及肿瘤的发生发展有密切关系。就目前知道的LIGHT在各种疾病中的作用综述。

关 键 词:LIGHT  自身免疫性疾病  移植物抗宿主病  感染  肿瘤

Progress in the role of LIGHT in disease
XU Sha,CHEN Li-li. Progress in the role of LIGHT in disease[J]. Progress In Microbiology and Immunology, 2013, 0(6): 66-70
Authors:XU Sha  CHEN Li-li
Affiliation:( School of Public Health, University of South China, Hengyang 421001, Hunan, China )
Abstract:LIGHT/TNFSF14 is a new member of the tumor necrosis factor (TNF ) superfamily, which can regulate the function of immune system through binding with herpesvirus entry mediator (HVEM) and lymphotoxinβ receptor (LTβR). Abundant studies revealed that LIGHT and its signal pathway participates in many aspects of pathologic processes, such as autoimmune diseases, graft versus host disease ( GVHD ) , pathogen infection and tumorigenesis. Here the complicate roles of LIGHT involved in various diseases were summarized.
Keywords:
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号