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Silica-based cationic bilayers as immunoadjuvants |
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| Authors: | Nilton Lincopan Mariana RA Santana Eliana Faquim-Mauro Maria Helena B da Costa Ana M Carmona-Ribeiro |
| Affiliation: | 1. Departamento de Bioquímica, Instituto de Química, Universidade de S?o Paulo, S?o Paulo, Caixa Postal 26077, S?o Paulo-SP, Brazil 2. Instituto Butantan, Av. Vital Brasil 1500, Butantan, 05503-900, Brazil |
| Abstract: | BackgroundSilica particles cationized by dioctadecyldimethylammonium bromide (DODAB) bilayer were previously described. This work shows the efficiency of these particulates for antigen adsorption and presentation to the immune system and proves the concept that silica-based cationic bilayers exhibit better performance than alum regarding colloid stability and cellular immune responses for vaccine design. |
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