Utilization Of Tetrabutylammonium Triphenyldifluorosilicate (TBAT) In The Synthesis of 6-Fluoropurine Nucleosides |
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| Authors: | Vadim Gurvich Hye-Young Kim Richard P. Hodge Constance M. Harris Thomas M. Harris |
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| Affiliation: | Department of Chemistry and Center in Molecular Toxicology , Vanderbilt University , Nashville, Tennessee, 37235 |
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| Abstract: | Abstract Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59–72%. |
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