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Antiviral Activity of Magnesium and Magnesium/poly r(A-U) Combinations Against two RNA Viruses |
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| Authors: | J Jamison J Gilloteaux M R Nassiri C C Tsai J Summers |
| Institution: | 1. Department of Urology , Summa Health System/N. E. Ohio Universities College of Medicine , 4209 St. Rt 44, P.O. Box 95, Rootstown, Ohio, 44272;2. Departments of Anatomy;3. Pharmacology/Virology, Lake Erie College of Osteopathic Medicine , 1858 W. Grandview Blvd., Erie, PA, 16509;4. Department of Chemistry , Kent State University , Kent, OH, 44242 |
| Abstract: | Abstract Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI) ? poly (rC), poly (dA-dT) ? poly (dA-dT) or poly (dG-dC) ? poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity. |
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