Use of Photolabile Amino-Protecting Groups in the Synthesis of Base-Sensitive DNA SATE-Phosphotriesters |
| |
| Authors: | Karine Alvarez Jean-Jacques Vasseur Jean-Louis Imbach |
| |
| Institution: | Laboratoire de Chimie Bio-Organique , UMR 5625 CNRS-UM II, Université Montpellier II, Place E. Bataillon, 34095, Montpellier Cedex, 5, France |
| |
| Abstract: | Abstract The first solid phase syntheses of prooligonucleotide heteropolymers carrying base-sensitive SATE phosphotriester linkages have been performed using the photolabile protecting groups 6-Nitroveratryloxycarbonyl (NVOC) and 2,2′-Di-(2-nitrophenyl)ethyloxycarbonyl) (diNPEOC) and a modified phosphoramidite approach. |
| |
| Keywords: | |
|
|
