The Prooligonucleotide Approach: Synthesis of Mixed SATE-Phosphotriester Phosphodiester Oligonucleotides |
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| Authors: | J C Bologna G Tosquellas F Morvan B Rayner J L Imbach |
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| Institution: | Laboratoire de Chimie Bio-Organique , UMR 5625, Université Montpellier II, Place E. Bataillon 34095, Montpellier Cedex, 5, (France) |
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| Abstract: | Abstract Synthesis of mixed SATE phosphotriester-phosphodiester prooligos was done following two ways. Phosphodiesters were generated by selective β-elimination of cyanoethyl using DBU or were introduced with H-phosphonate chemistry. |
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