A New Protecting Group Strategy for Amino Groups in Oligonucleotide Chemistry: CEOC Group |
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| Authors: | Muthiah Manoharan Thazha P Prakash Isabelle Barber-peoc'h Balkrishen Bhat Guillermo Vasquez Bruce S Ross |
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| Institution: | Department of Medicinal Chemistry , Isis Pharmaceuticals , 2292 Faraday Avenue, Carlsbad, CA, 92008, USA |
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| Abstract: | Abstract A new protecting group, 2-cyanoethyloxycarbonyl, or CEOC, has been developed for amino groups and utilized in synthesizing modified oligonucleotides. (CEOC)-oxy-succinimide reagent has been synthesized to introduce this protecting group. The protecting group is removed by standard oligonucleotide deprotection protocols. Using this approach, oligonucleotides have been synthesized with various types of alkylamine substituents. |
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