Parallel-Stranded Duplex DNA and Self-Assembled Quartet Structures Formed by Isoguanine and Related Bases |
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| Authors: | Frank Seela Changfu Wei Alexander Melenewski Elisabeth Feiling |
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| Institution: | Laboratorium für Organische und Bioorganische Chemie , Institut für Chemie, Universit?t Osnabrück , Babarastr 7, D-49069 , Osnabrück , Germany |
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| Abstract: | Abstract Parallel-stranded (ps) oligonucleotide duplexes are described containing isoguanine-cytosine and/or 5-methylisocytosine-guanine base pairs. A parallel hybrid is also formed when 5-aza-7-deazaguanine base pairs with guanine while the base pair with isoguanine results in an antiparallel duplex. Oligomers such as d(T4isoG4T4) form selfassembled tetraplexes which show a cation selectivity different from that of the G-quartet. |
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