Oligonucleotides with 2,6-Diaminopurine Base Replacing for Adenine: Synthesis and Properties |
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| Authors: | V. Boudou K. Rothenbacher A. Van Aerschot P. Herdewijn |
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| Affiliation: | Rega Institute, Laboratory of Medicinal Chemistry , KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium |
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| Abstract: | Abstract Synthesis of three nucleoside building blocks with a benzoyl protected diaminopurine (DAP) base and their incorporation at different positions of DNA, RNA and hexitol oligomers (HNA) have been accomplished. DNA hairpins with a DAP substituted for one (or more) adenine in the loop structure were not found to be more stable. But the stability of RNA-hexitol as well as hexitol-hexitol duplexes improved when the adenine base was replaced with DAP. |
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