Acyclo C-Nucleoside Analogs. Regioselective Annellation of a Triazole Ring to 5-Methyl-1,2,4-Triazino[5,6-b]Indole and Formation of Certain 3-Poly Hydroxyalkyl Derivatives |
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| Authors: | Nagwa Rashed Hamida Abdel Hamid El Sayed Ramadan El Sayed H El Ashry |
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| Institution: | Chemistry Department, Faculty of Science , Alexandria University , Alexandria, Egypt |
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| Abstract: | ABSTRACT Cyclodehydrogenation of the ethylidene derivative of (5-methyl-1,2,4-triazino5,6-b]indol-3-yl)hydrazine (1) gave the angular isomer, 1,10-dimethyl-1,2,4-triazolo3′,4′:3,4]1,2,4]triazino5,6-b]indole (4). The linear isomer, 3,10-dimethyl-1,2,4-triazolo4′,3′:2,3]1,2,4]triazino5,6-b]indole (7) could be prepared regioselectively by the cyclodehydration of the acetyl derivative of 1. The cyclodehydrogenation was extended to the monosaccharide derivatives of 1. The role of the N-methyl group on the site of annellation has been discussed. |
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