Deamination of Cyclaradine by Adenosine Deaminase Under High Pressure# |
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| Authors: | Nobuya Katagiri Hideaki Kokufuda Masashi Makino Robert Vince Chikara Kaneko |
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| Institution: | Pharmaceutical Institute, Tohoku University , Aobayama, Aoba-ku, Sendai, 980-77, Japan |
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| Abstract: | Abstract The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure. |
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