|
|||||
|
|
A Biotin Phosphoramidite Reagent for the Automated Synthesis of 5′-Biotinylated Oligonucleotides |
|
| Authors: | Zhengyun Zhao John Ackroyd |
| Institution: | Cruachem Limited, Todd Campus, West of Scotland Science Park , Acre Road, Glasgow, G20 OUA |
| Abstract: | Abstract A bis(DMTr)biotin phosphoramidite containing serine and 6-aminohexanol moieties was prepared by a multiple-step reaction, and used successfully in the solid phase synthesis of 5′-biotinylated oligonucleotides. |
| Keywords: | |